Preventing Dysgeusia & Maximizing Eyedrops Absorption

Eyedrops are like excessive tear that naturally drain through the tear ducts into the throat. Eyedrops medications rely on you to keep the eyedrops in your eyes so that the medications will infuse fully into your eyes to be  effective rather than partially drain through the tear ducts into the throat causing possible systemic side effects. The delivery of eyedrops medication will improve if you occlude the tear duct to prevent the outflow. This procedure is known as Tear Duct Occlusion (also known as Nasolacrimal Occlusion, or NLO). The benefits of applying NLO while administering eyedrops are:

  1. lowering IOP (Intraocular Pressure) by enabling deliver of full dosage of eyedrops medication to maintain higher medication level in your eyes. (Without NLO, delivering full dosage of eyedrops into the eyes is not possible.)
  2. postponing glaucoma surgery for patients run out of eyedrop options.
  3. Reduce systemic side effects, such as dysgeusia (a bitter aftertaste in the mouth), low blood pressure, reduced pulse rate, fatigue and depression which mostly come from beta blockers type of eyedrops while dysgeusia is the biggest complaint of dry eye patients who use Xiidra eyedrops.

These benefit claims are supported by the following clinical studies:

“Well-designed clinical studies suggest that NLO (nasolacrimal occlusion) and ELC (eyelid closure) for 5 minutes improve intraocular penetration of topically applied glaucoma medications and discourage systemic absorption.” –  Trans Am Ophthalmol Soc. 2008 Dec; 106: 138–148 by Allan J. Flash. (more…)

“The intraocular pressures in plug the (punctal plug) plugged eyes decreased an average of 1.82 mm Hg after punctal occlusion when compared to before punctal occlusion (P = .001).” – Am J Ophthalmol 1989 Feb 15;107(2):151-5 by Huang TC. (more…)

“Punctal occlusion significantly decreased the intraocular pressure with an average of 2.00 +/- 0.43 mmHg in the plugged eyes (p < 0.001).” – Acta Ophthalmol Scand 1996 Aug;74(4):411-3. by Ariturk N, Oge I, Erkan D, Sullu Y, Sahin M. (more…)

Our own clinical study shows that Tear Duct Occluder lowered IOP by 2.00 +/- 0.5 mmHg (p<0.001).

Manual NLO  -the Current Standard of Care

IMG_1298 (6)The patient on the left used to use her finger to press against her tear duct while administering drops but her IOP was still not low enough and she was due for glaucoma surgery. Our clinical study shows only 10% of glaucoma patients practice manual NLO correctly; 14% patients practice manual NLO for less than a minute; 14% patients do not practice manual NLO regularly and 62% do not practice NLO at all.

Tear Duct OccluderTMthe Most Effective NLO

IMG_1299 (2)After using Tear Duct Occluder for two months, this patient’s IOP became low enough to postpone her glaucoma surgery indefinitely.

Tear Duct Occluder can occlude both tear ducts for you while you are administering eyedrops.  It eliminates the burden of pressing the tear duct by hand and give you freedom to do other things. It increases your adherence to practicing Tear Duct Occlusion as your doctor advised and therefore, improves your eye healthcare. You simply wear this device while instilling the eyedrops and continue wearing it for 5 more minutes after the instillation. Repeat this process for additional eyedrops, if any. Our clinical data shows that Tear Duct Occluder fits 90% of patients without needing adjustment; 90% of glaucoma patients have high interest on this device; 10% of patients have moderate interest on this device and 10% of all patients do away with surgery.